Human papillomavirus and related diseases: from bench to bedside: a clinical perspective

Cervical cancer is the second most prevalent cancer among women worldwide, mainly affecting young women. Infection with Human Papilloma Virus (HPV) has been identified as the causal agent for this condition. The natural history of cervical cancer is characterized by slow disease progression, generally taking over 10 years, from the initial infection with HPV, to the diagnosis of cancer. In essence, cervical cancer is a preventable disease, and treatable if diagnosed in early stage. Historically, the introduction of the Pap smear has markedly reduced the number of new cases in countries with an effective prevention program. The burden of disease is highest in developing countries, with peak incidence in Eastern Africa. Recently, prophylactic vaccines became available, equally contributing to a better disease prevention. Unfortunately, the global burden of disease is still very high.
In the first section of this book, clinical aspects of HPV related disease are highlighted.
Innovative clinical diagnostic tools are discussed and Dr Fedrizzi has provided a highly illustrative contribution on the clinical manifestation of HPV related disease.
The introduction of the HPV prophylactic vaccine has been an important recent development in the fight against cervical cancer. The second section focuses on HPV vaccine related issues. Immune responses of the current vaccine are presented by Dr Bourgault-Villada, and options for the next generation vaccines, or more efficient production strategies, are discussed. Although HPV is most prominently known from its role in cervical carcinogenesis, the virus is also involved in other conditions. In the third section, HPV in non-uterine disease is discussed. Epidemiology and role of HPV in head-and-neck tumors are addressed. HPV also affects men, and this section covers the impact of HPV on penile cancers and its prevalence in semen.
This book will be a useful tool for both researchers and clinicians dealing with cervical cancer, and it will provide them with the latest information in this field.

Authors & affiliation: 
Davy Vanden Broeck; ICEH UGent De Pintelaan 185 UZ P114 9000 Gent Belgium
Staff Members: 
Published In: 
Human papillomavirus and related diseases: from bench to bedside: a clinical perspective - ISBN9789533078601; publisher InTech
Publication date: 
Monday, January 16, 2012