Human papillomavirus: E6 and E7 oncogenes

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The recognition of a causal relationship between human papillomaviruses and cancer almost 30 years ago led to a rapid expansion of knowledge in the field, resulting in the description of the main mediators of HPV-induced carcinogenesis, the viral proteins E6 and ET These oncoproteins show a remarkable pleiotropism in binding host-cell proteins, with the tumour suppressor genes p53 and pRb as their major targets. These interactions induce proliferation, immortalization and malignant transformation of infected cells.

The link between HPV and cervical cancer led to the development of molecular methods, often based on the detection of E6 and E7, for screening and diagnosis. Therapeutic vaccines and gene therapy are primarily directed at E6 and ET Although prophylactic vaccines are available, further understanding of the viral life cycle and the mechanisms underlying HPV-induced oncogenesis is necessary to face the many challenges in the field of HPV and cancer.

Authors & affiliation: 
Gaelle Boulet a, Caroline Horvath a, Davy Vanden Broeck b, Shaira Sahebali a, Johannes Bogers a A AMBIOR, Laboratory for Cell Biology & Histology, University of Antwerp, Groenenborgerlaan 171, BE-2020 Antwerp, Belgium B International Centre for Reproductive Health (ICRH), Ghent University, De Pintelaan 185, 9000 Ghent, Belgium
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Published In: 
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY Volume: 39 Issue: 11 Pages: 2006-2011
Publication date: 
Thursday, July 19, 2007